Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa_circ_0001821
Specific or universal ncRNAs
Universal ncRNAs
Class
Circular RNA
Biomarker
Yes
Biomarker application
Diagnosis/Treatment
Upstream regulatory factors
Not available
Downstream target
ABCB1
Cancer name
Osteosarcoma
Cancer site
Bone, Articular Cartilage
Treatment type
Chemotherapy
Drug
Cisplatin/Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
80
Male patients
47
Female patients
33
Age range and number
56(<25)+24(>=25)
PMID
Description
Overexpressed circPVT1 contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1.
Tissue resource
primary osteosarcoma
human osteosarcoma cell lines SaoS2
human osteosarcoma cell lines KHOS
human osteosarcoma cell lines U2OS
human osteosarcoma cell lines MG63
Experiment
RT-PCR,Western blot
Institute
Shanghai Tenth People's Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.