Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
PTCSC3
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Upstream regulatory factors
Not available
Downstream target
STAT3/INO80
Cancer name
Anaplastic Thyroid Cancer
Cancer site
Thyroid
Treatment type
Chemotherapy
Drug
Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
LncRNA PTCSC3 inhibits INO80 expression by negatively regulating STAT3, and thereby attenuating drug resistance of ATC to chemotherapy drug doxorubicin.
Tissue resource
follicular thyroid cancer tissues and anaplastic thyroid carcinoma tissues
human thyroid carcinoma anaplastic thyroid carcinoma cell lines 8505
human thyroid carcinoma follicular thyroid cancer cell lines 238
Experiment
RT-PCR,Western blot
Institute
the First Affiliated Hospital of Zhengzhou University
European Collection of Animal Cell Cultures
Country
China
UK
Continent
Asia
Europe
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.