Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-377
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
XIAP
Cancer name
Osteosarcoma
Cancer site
Bone, Articular Cartilage
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Down-regulation of miR-377 contributes to cisplatin resistance by targeting XIAP in osteosarcoma.
Tissue resource
osteosarcoma tissue samples
osteosarcoma cisplatin-resistant cell lines MG-63/CDDP
osteosarcoma cisplatin-resistant cell lines Saos-2/CDDP
osteosarcoma cell lines MG-63
osteosarcoma cell lines Saos-2
Experiment
RT-PCR,Western blot,Luciferase reporter assay
Institute
Hubei Cancer Hospital
Shanghai Cell Bank of Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.