hsa-miR-574

ncRNA information

ncRNA name

hsa-miR-574

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

SMAD4

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Doxorubicin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

We revealed miR-574 could promote doxorubicin resistance of breast cancer MCF-7 cells via down-regulating SMAD4, thus providing a novel target for advancing breast cancer chemotherapy.

Tissue resource

blood samples of breast cancer patients

breast cancer cell lines MCF-7

breast cancer adriamycin-resistant cell lines MCF-7/ADR

Experiment

qRT-PCR,Western blot,Dual-luciferase reporter assay


Institute

Yantai Yuhuangding Hospital

KeyGENE

Country

China

Continent

Asia