Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
NEAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
let-7a-5p/Rsf-1
Cancer name
Nasopharyngeal Carcinoma
Cancer site
Nasopharynx
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
These findings suggest that NEAT1/let-7a-5p regulates the cisplatin resistance in NPC by targeting Rsf-1 and modulating the Ras-MAPK signaling pathway.
Tissue resource
nasopharyngeal carcinoma tissues and paired adjacent normal tissues
nasopharyngeal carcinoma cell lines HK-1
nasopharyngeal carcinoma cell lines CNE-1
nasopharyngeal carcinoma cell lines S18
nasopharyngeal carcinoma cell lines 5–8F
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Henan Provincial People's Hospital
China Center for Type Culture Collection
the Chinese Academy of Sciences
the Cancer Research Institute of Sun Yatsen University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.