Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-374b-5p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Pancreatic Cancer
Cancer site
Pancreas
Treatment type
Chemotherapy
Drug
Gemcitabine
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
87
Male patients
51
Female patients
36
Age range and number
28(<=60)+59(>60)
PMID
Description
Importantly, the upregulation of miR-374b-5p ameliorated the chemoresistance of pancreatic cancer cells to gemcitabine in vivo.
Tissue resource
pancreatic cancer tissues and adjacent normal tissues
human pancreatic cancer cell lines BxPC-3
human pancreatic cancer cell lines PANC-1
human pancreatic cancer cell lines AsPC-1
human pancreatic cancer cell lines SW1990
human pancreatic cancer cell lines Capan-1
human pancreatic cancer cell lines Capan-2
human pancreatic cancer cell lines CFPAC-1
human pancreatic cancer cell lines MIA PaCa-2
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
the First Hospital of Jilin University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.