Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
MALAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-145-5p/AKAP12
Cancer name
Prostate Cancer
Cancer site
Prostate
Treatment type
Chemotherapy
Drug
Docetaxel
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
It was proved that MALAT1 promoted tumour cell proliferation and enhanced DTX-chemoresistance in vivo.
Tissue resource
prostate cancer tissues
human prostate cancer cell lines DU145
human prostate cancer cell lines PC3
human embryonic kidney cell lines HEK-293T
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
the Third Affiliated Hospital of Suzhou University
BeNa Culture Collection Biological Technology Co., Ltd
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.