hsa-miR-195

ncRNA information

ncRNA name

hsa-miR-195

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

CLU

Cancer information

Cancer name

Prostate Cancer

Cancer site

Prostate

Treatment information

Treatment type

Chemotherapy

Drug

Docetaxel

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Our results illuminated that miR-195 improved the sensitivity of resistant PC cells to DOC by suppressing CLU. Hence, miR-195 may be a potentially promising molecular target for drug resistance of PC.

Tissue resource

prostate cancer cell lines DU145

prostate cancer docetaxel-resistant cell lines DU145/DOC

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

American Type Culture Collection

Country

USA

Continent

North American