Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-98-5p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
Dicer1
Cancer name
Epithelial Ovarian Cancer
Cancer site
Ovary
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
97
Male patients
42
Female patients
55
Age range and number
Not available
PMID
Description
MiR-98-5p contributes to cisplatin resistance in epithelial ovarian cancer by suppressing miR-152 biogenesis via targeting Dicer1.
Tissue resource
normal ovarian epithelial tissues、borderline ovarian tumor tissues and epithelial ovarian carcinoma tissues
human ovarian cancer cell lines C13*
human ovarian cancer cell lines OV2008
human ovarian cancer cell lines A2780
human ovarian cancer cisplatin-resistant cell lines A2780/DDP
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Shanghai General Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.