Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-146a
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
CHOP
Cancer name
Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Abnormally expressed miR-146a in lung cancer cells does not affect growth, but rather alters chemotherapy sensitivity.
Tissue resource
lung adenocarcinoma tumor tissues
human lung cancer cell lines A549
human lung cancer cell lines H446
human lung cancer cisplatin-resistant cell lines A549/CDDP
human lung cancer cisplatin-resistant cell lines H446/CDDP
Experiment
qRT-PCR,Dual-luciferase reporter assay
Institute
the Southwest Hospital of Third Military Medical University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.