CTRR-ncRNA

ncRNA information

ncRNA name

APCDD1L-AS1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-1224-5p/NSD2

Cancer information

Cancer name

Oral Squamous Cell Carcinoma

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

8-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

29

Male patients

11

Female patients

17(<=50)+23(>50)

Age range and number

Not available

Research information

PMID

34546854

Description

our study demonstrated that exosomal APCDD1L-AS1 conferred resistance to 5-FU in HSC-3/5-FU and HN-4/5-FU cells via the miR-1224-5p/NSD2 axis

Tissue resource

ovarian squamous cell carcinoma tissues and adjacent normal tissues

ovarian squamous cell carcinoma cell lines SCC-4

ovarian squamous cell carcinoma cell lines HSC-3

ovarian squamous cell carcinoma cell lines TSCC1

ovarian squamous cell carcinoma cell lines SCC090

ovarian squamous cell carcinoma cell lines HN-4

normal human oral keratinocyte cell line NHOK

Experiment

40

Institute

Henan Provincial People's Hospital

BeNa Culture Collection

Country

China

Continent

Asia