Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-148a-3p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
SPIN1
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Adriamycin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
40(<=50)+38(>50)
PMID
Description
Our results establish that SPIN1, negatively regulated by the miR-148/152 family, enhances Adriamycin resistance in breast cancer via upregulating the expression of drug metabolizing enzymes and drug transporter.
Tissue resource
prechemotherapy needle biopsy samples and the paired surgically removed breast cancer samples
prechemotherapy needle biopsy samples and the paired surgically removed breast cancer samples
prechemotherapy needle biopsy samples and the paired surgically removed breast cancer samples
human breast cancer cell lines MCF-7
human breast cancer cell lines MDA-MB-231
human breast cancer cell lines MDA-MB-468
human breast cancer cell lines MCF-7
human breast cancer cell lines MDA-MB-231
human breast cancer cell lines MDA-MB-468
human breast cancer cell lines MCF-7
human breast cancer cell lines MDA-MB-231
human breast cancer cell lines MDA-MB-468
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Qilu Hospital of Shandong University
American Type Culture Collection
American Type Culture Collection
American Type Culture Collection
Country
China
USA
USA
USA
Continent
Asia
North American
North American
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.