CTRR-ncRNA

ncRNA information

ncRNA name

UCA1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-129/ABCB1

Cancer information

Cancer name

Ovarian Cancer

Cancer site

Ovary

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

29777711

Description

UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1.

Tissue resource

human embryonic kidney cell lines HEK-293T

human ovarian cancer cell lines SKOV3

human ovarian cancer cell lines HeyA-8

human ovarian cancer paclitaxel-resistant cell lines SKOV3/PTX

human ovarian cancer paclitaxel-resistant cell lines HeyA-8/PTX

Experiment

qRT-PCR,Western blot,Luciferase reporter assay

Institute

Country

Continent