Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-129-5p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
SOX2
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Adriamycin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
It was suggested that miR-129-5p suppresses Adriamycin resistance in breast cancer by directly targeting SOX2.
Tissue resource
pairs of breast cancer tissues and matching adjacent normal tissues
breast adriamycin-resistant cell lines MCF-7/ADR
breast adriamycin-resistant cell lines MDA-MB-231/ADR
human breast cancer cell lines MDA-MB-231
human breast cancer cell lines MCF-7
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Jinling Hospital, affiliated with the Medical School of Nanjing University
Keygen Company
RunChuang Company
the Type Culture Collection of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.