HOTAIR

ncRNA information

ncRNA name

HOTAIR

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Wnt

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Si-HOTAIR interference significantly decreased the sensitivity of cells to DDP.

Tissue resource

non-small cell lung cancer and cancer-adjacent tissues

human lung adenocarcinoma cell lines NCI-H1299

Experiment

qRT-PCR,Western blot


Institute

the Peking Union Medical College Hospital

the Cell Bank, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Country

China

Continent

Asia