Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-663b
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
TP73
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Tamoxifen
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
It was identified that downregulation of miRNA-663b inhibited cell proliferation ability and promoted cell apoptosis, resulting in enhanced TAM sensitivity.
Tissue resource
human breast cancer tissues with tamoxifen resistance and the control tissues
human breast cancer cell line MCF7
tamoxifen resistant breast cancer cell line MCF7/TAM
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
The Third Affiliated Hospital of Sun Yat-sen University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.