Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
LINC00152
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Adriamycin/Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Knock-down of Linc00152 in MCF-7/ADR cells reversed the chemo-resistance to doxorubicin.
Tissue resource
breast cancer tissues and adjacent normal tissues
normal human mammary epithelial cell lines MCF-10A
human breast cancer cell lines SKBR3
human breast cancer cell lines MDA-MB-231
human breast cancer cell lines MCF-7
human breast adenocarcinoma multidrug-resistant cell lines MCF-7/ADR
Experiment
qRT-PCR,Western blot
Institute
the Shenzhen People's Hospital
Shanghai Cell Institute of Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.