Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-16
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
IKBKB
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
The inhibition of miR-16 renders resistance to paclitaxel in vitro and in vivo by targeting IKBKB via NF-kB signaling pathway.
Tissue resource
normal liver cell lines LO2
human hepatocellular carcinoma cell lines SMMC-7721
human hepatocellular carcinoma cell lines PLC
human hepatocellular carcinoma cell lines BEL-7402
human hepatocellular carcinoma cell lines BEL-7404
human hepatocellular carcinoma cell lines HepG2
human hepatocellular carcinoma cell lines HCCLM3
Experiment
qRT-PCR,Western blot
Institute
Sun Yat-sen University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.