Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
KCNQ1OT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-7-5p/ABCC1
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
Oxaliplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Moreover, knockdown of KCNQ1OT1 inhibited the cell proliferation, migration, invasion and reduced the expression of drugresistant gene (MRP5, MDR1, LRP1).
Tissue resource
paired gastric cancer tissues and adjacent non-cancerous tissues
hepatocellular carcinoma cell lines SMMC-7721
hepatocellular carcinoma cell lines Huh7
hepatocellular carcinoma cell lines SK-Hep-1
hepatocellular carcinoma cell lines HepG2
normal liver cell lines Lo-2
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
the Affiliated Longhua Central Hospital of Guangdong Medical University
the Chinese Academy of Sciences Cell Bank
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.