Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-760
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Notch1/Hes1-PTEN/Akt Signaling pathway
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our results demonstrate that miR-760 inhibits Dox-resistance in HCC cells through inhibiting Notch1 and promoting PTEN expression.
Tissue resource
normal liver cell lines HL-7702
human hepatocellular carcinoma cell lines Huh-7
human hepatocellular carcinoma cell lines HepG2
human hepatocellular carcinoma cell lines SMMC-7221
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
Type Culture Collection of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.