hsa-miR-760

ncRNA information

ncRNA name

hsa-miR-760

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Notch1/Hes1-PTEN/Akt Signaling pathway

Cancer information

Cancer name

Hepatocellular Carcinoma

Cancer site

Liver

Treatment information

Treatment type

Chemotherapy

Drug

Doxorubicin

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Our results demonstrate that miR-760 inhibits Dox-resistance in HCC cells through inhibiting Notch1 and promoting PTEN expression.

Tissue resource

normal liver cell lines HL-7702

human hepatocellular carcinoma cell lines Huh-7

human hepatocellular carcinoma cell lines HepG2

human hepatocellular carcinoma cell lines SMMC-7221

Experiment

qRT-PCR,Western blot,Dual-luciferase reporter assay


Institute

Type Culture Collection of the Chinese Academy of Sciences

Country

China

Continent

Asia