Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-31
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
SOX10
Cancer name
Melanoma
Cancer site
Skin
Treatment type
Chemotherapy
Drug
Dacarbazine
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
94
Male patients
55
Female patients
39
Age range and number
Not available
PMID
Description
Our results demonstrated that SOX10 acted as an oncogene and was negatively regulated by miR-31, which supports the potential therapeutic strategy against melanoma by targeting the miR-31-SOX10.
Tissue resource
pairs of melanoma and adjacent normal tissues
melanoma cell lines A375
melanoma cell lines A2058
melanoma cell lines SKMEL13
melanoma cell lines HT144
melanoma cell lines SKMEL5
melanoma cell lines A875
melanoma cell lines SKMEL1
melanoma cell lines M21
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.