hsa-miR-31

ncRNA information

ncRNA name

hsa-miR-31

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

SOX10

Cancer information

Cancer name

Melanoma

Cancer site

Skin

Treatment information

Treatment type

Chemotherapy

Drug

Dacarbazine

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

94

Male patients

55

Female patients

39

Age range and number

Not available

Research information

PMID

Description

Our results demonstrated that SOX10 acted as an oncogene and was negatively regulated by miR-31, which supports the potential therapeutic strategy against melanoma by targeting the miR-31-SOX10.

Tissue resource

pairs of melanoma and adjacent normal tissues

melanoma cell lines A375

melanoma cell lines A2058

melanoma cell lines SKMEL13

melanoma cell lines HT144

melanoma cell lines SKMEL5

melanoma cell lines A875

melanoma cell lines SKMEL1

melanoma cell lines M21

Experiment

qRT-PCR,Western blot,Dual-luciferase reporter assay


Institute

The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University

American Type Culture Collection

Country

China

USA

Continent

Asia

North American