Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
GAS5
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Prognosis
Upstream regulatory factors
Not available
Downstream target
miR-222
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Tamoxifen
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
We further found that GAS5 overexpression enhanced cell sensitivity to tamoxifen in MCF-7R cells both in vitro and in vivo.
Tissue resource
breast cancer tissues and adjacent normal tissues
human breast cancer tamoxifen-sensitive cell lines MCF-7
human breast cancer tamoxifen-resistant cell lines MCF-7R
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
Wuxi Clinical Hospital of Nanjing Medical University
the Cell Bank of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.