Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
LINC00518
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-199a/MRP1
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Adriamycin/Paclitaxel/Vincristine
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
30
Male patients
Not available
Female patients
Not available
Age range and number
8(<50)+22(>=50)
PMID
Description
Linc00518 downregulation reduced MDR byregulating miR-199a/MRP1 in breast cancer.
Tissue resource
pairs of breast cancer tissue specimens and the adjacent normal tissues
human mammary epithelial cell lines MCF-10A
human breast cancer cell lines MCF-7
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Huaihe Hospital of Henan University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.