Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-451
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
HDAC3
Downstream target
NEDD9
Cancer name
Prostate Cancer
Cancer site
Prostate
Treatment type
Chemotherapy
Drug
Docetaxel
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
The current data revealed a new HDAC3/Sp1/miR-451/NEDD9 signaling that regulates the chemosensitivity of prostate cancer cells and represents a novel therapeutic target for chemosensitizing mCRPC.
Tissue resource
prostate cancer tissues and metastatic castration-resistant tissues
normal prostate epithelial cell line benign prostate hyperplasia BPH-1
human prostate cancer cell lines LNCaP
human prostate cancer cell lines PC3
human prostate cancer cell lines DU145
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Jinling Hospital
the Shanghai Institute of Cell Biology
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.