Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-26a
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
E2F7
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Tamoxifen
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Both miR-26a knockdown and E2F7 overexpression conferred resistance to TAM in MCF-7 cells.
Tissue resource
pairs of ER-positive breast cancer and normal adjacent breast tissues
breast cancer cell lines MCF-7
breast cancer cell lines T47D
breast cancer cell lines BT474
breast cancer cell lines SKBR3
breast cancer cell lines MDA-MB-231
breast cancer cell lines Hs578T
normal breast cell lines MCF-10A
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the First Affiliated Hospital of Xi'an Jiaotong University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.