Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-499a-5p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
PI3K/Akt/PTEN
Cancer name
Pancreatic Cancer
Cancer site
qRT-PCR,Western blot,Luciferase assay
Treatment type
Chemotherapy
Drug
5-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-499a-5p promotes 5-FU resistance and the cell proliferation and migration through activating PI3K/Akt signaling by targeting PTEN in pancreatic cancer
Tissue resource
prostate tissues together with corresponding normal adjacent tissues from prostate patients
human embryonic kidney cell lines 293T
human prostate cell lines Mia-capa2
human prostate cell lines PANC1
human prostate cell lines AsPC-1
human prostate cell liness Capan-2
human pancreas cell lines HPDE6-C7
human 5-5-Fluorouracil-resistant pancreas cell lines ANC1/FU
Experiment
None
Institute
Changhai Hospital
the Chinese Academy of Sciences
Mei Xuan Biological Science and Technology Ltd
Country
China
China
China
Continent
Asia
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.