Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
SNHG12
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-320a/MCL1
Cancer name
Osteosarcoma
Cancer site
Bone, Articular Cartilage
Treatment type
Chemotherapy
Drug
Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Knockdown of SNHG12 contributed to the upregulation of miR-320a and improved the sensitivity of doxorubicin.
Tissue resource
primary osteosarcoma
human osteosarcoma cell lines MG-63
human osteosarcoma cell lines U2OS
human osteosarcoma cell lines HOS
human osteosarcoma cell lines SAOS-2
human osteoblastic cell lines hFOB
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
the Affiliated Longhua Central Hospital of Guangdong Medical University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.