Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-185
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
ZNF139
Downstream target
Not available
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
5-Fluorouracil/Adriamycin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Transfection with pcDNA-ZNF139 in GC cell line SGC7901 resulted in an increased expression level of ZNF139 and a decline in the expression level of miR-185.
Tissue resource
clinical samples of gastric cancer and para-cacinoma tissues
human gastric cancer cell lines GES-1
human gastric cancer cell lines SGC7901
gastric cancer adriamycin-resistant cell lines SGC7901/ADR
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
The Fourth Hospital of Hebei Medical University
Shanghai Institutes of Biochemistry and Cell Biology
The Fourth Hospital of Hebei Medical University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.