Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
SNHG3
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-128/CD151
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
Sorafenib
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
33
Male patients
22
Female patients
11
Age range and number
Not available
PMID
Description
Forced expression of SNHG3 promoted cell invasion, epithelial mesenchymal transition (EMT), and sorafenib resistance in HCC.
Tissue resource
specimens of normal human liver and hepatocellular carcinoma tissues
hepatocellular carcinoma cell lines PLC/PRF/5
hepatocellular carcinoma cell lines Hep3B
hepatocellular carcinoma cell lines HepG2
hepatocellular carcinoma cell lines MHCC97L
hepatocellular carcinoma cell lines Huh 7
hepatocellular carcinoma cell lines SMMC-7721
hepatocellular carcinoma cell lines HCCLM3
Experiment
qRT-PCR,Western blot
Institute
the Zhongshan Hospital of Fudan University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.