CTRR-ncRNA

ncRNA information

ncRNA name

hsa_circ_0058493

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Not available

Cancer information

Cancer name

Chronic Myeloid Leukemia

Cancer site

qRT-PCR

Treatment information

Treatment type

Chemotherapy

Drug

Imatinib

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

53

Male patients

37

Female patients

40(<40)+46(40-60)+4(>=60)

Age range and number

Not available

Research information

PMID

34588984

Description

hsa_circ_0058493 was significantly enriched in the exosomes derived from imatinib-resistant CML cells

Tissue resource

peripheral blood samples from CML patients

Imatinib-sensitive K562 cells

imatinib-resistant K562/G01 cells

Experiment

90

Institute

the hematology department of Xiangya Hospital and Second Xiangya Hospital of Central South University

Institute of Clinical Pharmacology

Tianjin Institute of Hematology

Country

China

Continent

Asia