hsa-miR-214

ncRNA information

ncRNA name

hsa-miR-214

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

ABCB1

Cancer information

Cancer name

Chronic Myeloid Leukemia

Cancer site

Leukemia

Treatment information

Treatment type

Chemotherapy

Drug

Imatinib/Mesylate

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Up

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

57

Male patients

34

Female patients

23

Age range and number

Not available

Research information

PMID

30186389

Description

Elevated expression of miR-214 restored IM sensitivity to K562R cells potentially by affecting ABCB1 expression.

Tissue resource

blood from chronic myeloid leukemia patients with imatinib resistance and chronic myeloid leukemia patients

chronic myeloid leukemia cell lines K562

Experiment

qRT-PCR,Dual-luciferase reporter assay

Institute

the Jining No.1 People's Hospital

American Type Culture Collection

Country

China

USA

Continent

Asia

North American

Institutes for Systems Genetics, West China Hospital
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