Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-185
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Diagnosis/Treatment
Upstream regulatory factors
Not available
Downstream target
SOX13
Cancer name
Non-Small Cell Lung Carcinoma
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-185 regulated cell proliferation, migration, invasion and increased chemo-sensitivity in H1975 cells by inhibiting SOX13.
Tissue resource
human non-small cell lung cancer specimens and adjacent normal tissues
non-small cell lung cancer cell lines A549
non-small cell lung cancer cell lines H1975
non-small cell lung cancer cell lines H1650
non-small cell lung cancer cell lines HCC-827
human bronchial epithelial cell lines BEAS-2B
Experiment
qRT-PCR,Dual-luciferase reporter assay
Institute
the Affiliated Hospital of Medical School of Ningbo University
Sciences Cell Bank of Type Culture Collection
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.