Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
FGD5-AS1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-330-3p
Cancer name
Colon Cancer
Cancer site
None
Treatment type
Chemotherapy
Drug
18-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
37
Male patients
43
Female patients
11(<20)+47(20-50)+22(>50)
Age range and number
Not available
PMID
Description
Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis
Tissue resource
5-Fu-resistant colon tumor specimens and 5-Fu-sensitive colon tumors were collected from colorectal cancer patients
human colon cancer cell lines LoVo
human colon cancer cell lines HCT-116
human colon cancer cell lines HT-29
human colon cancer cell lines DLD-1
Experiment
80
Institute
the China-Japan Union Hospital of Jilin University
American Type Culture Collection
Country
China
United States
Continent
Asia
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.