Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-340-5p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
LGR5
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Docetaxel
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
our study demonstrated that overexpressed miR-340-5p inhibited cell proliferation and drug resistance with increased apoptosis of breast cancer cells through down-regulating LGR5 expression via Wnt/Ī²-catenin pathway
Tissue resource
human breast epithelial cell lines MCF10A
breast cancer cell lines MCF-7
breast cancer cell lines MDA-MB-231
breast cancer cell lines BT-549
breast cancer cell lines ZR-75-1
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
American Type Culture Collection
Country
USA
Continent
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.