Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-495-3p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Prognosis/Treatment
Upstream regulatory factors
Not available
Downstream target
GRP78/mTOR
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Adriamycin/Vincristine
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MicroRNA-495-3p inhibits multidrug resistance by modulating autophagy through GRP78/mTOR in gastric cancer.
Tissue resource
frozen paired gastric cancer patients'specimens
human gastric adenocarcinoma cell lines SGC7901
human gastric adenocarcinoma adriamycin-resistant cell lines SGC7901/ADR
human gastric adenocarcinoma vincristine-resistant cell lines SGC7901/VCR
Experiment
Western blot,Luciferase reporter assay
Institute
the First Affiliated Hospital of the Fourth Military Medical University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.