Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
MALAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-30b/ATG5
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MALAT1 potentiated autophagy-related CDDP resistance through suppressing the miR-30b/ATG5 in AGS/CDDP and HGC-27/CDDP cells, indicating that it may represent a promising target for the reversal of chemoresistance in GC.
Tissue resource
human gastric cancer cell lines AGS
human gastric cancer cell lines HGC-27
human embryonic kidney cell lines HEK-293T
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
American Type Culture Collection
the cell bank of the Chinese Academy of Sciences
Country
USA
China
Continent
North American
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.