MALAT1

ncRNA information

ncRNA name

MALAT1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-328

Cancer information

Cancer name

Chronic Myelogenous Leukemia

Cancer site

Leukemia

Treatment information

Treatment type

Chemotherapy

Drug

Imatinib

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

LncRNA MALAT1/miR-328 promotes the proliferation and imatinib resistance of CML cells, providing new perspectives for the future study of MALAT1 as a therapeutic target for CML.

Tissue resource

human chronic myeloid leukemia cell lines K562

human chronic myeloid leukemia cell lines KG-1

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

American Type Culture Collection

Country

USA

Continent

North American