CASC2

ncRNA information

ncRNA name

CASC2

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-19a

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Down

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

CASC2 overexpression overcame DDP resistance in gastric cancer by sponging miR-19a, providing a novel therapeutic target for gastric cancer chemoresistance.

Tissue resource

gastric cancer tumor tissues and their matched adjacent normal tissues

human fetal gastric epithelial cell lines GES-1

human gastric cancer cell lines BGC823

human gastric cancer cell lines SGC7901

human gastric cancer cisplatin-resistant cell lines BGC823/DDP

human gastric cancer cisplatin-resistant cell lines SGC7901/DDP

Experiment

qRT-PCR,Luciferase reporter assay


Institute

the First Affiliated Hospital of Zhengzhou University

American Type Culture Collection

Country

China

USA

Continent

Asia

North American