Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
GAS5
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-221/SOCS3
Cancer name
Pancreatic Cancer
Cancer site
Pancreas
Treatment type
Chemotherapy
Drug
Gemcitabine
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
The results show that overexpression of GAS5 suppressed the proliferation, migration, gemcitabine resistance, stem celllike properties, and epithelial-mesenchymal transition (EMT) of PC cells by directly binding to and suppressing miR-221 expression and enhancing suppressor of cytokine signaling 3 (SOCS3) expression.
Tissue resource
carcinomas and adjacent tissue
human pancreatic cancer cell lines PANC-1
human pancreatic cancer cell lines AsPC-1
human pancreatic cancer cell lines Capan-2
human pancreatic cancer cell lines SW1990
human pancreatic cancer cell lines BXPC-3
human pancreatic ductal epithelial cell lines HPDE6-C7
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Tongren Hospital of Shanghai Jiaotong University School of Medicine
the laboratory of biliary-pancreatic surgery at Tongren Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.