Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa_circ_0100181
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
No
Biomarker application
Prognosis/Treatment
Upstream regulatory factors
Not available
Downstream target
miR-153-5p/miR-183-5p-XIAP
Cancer name
Acute Myeloid Leukemia
Cancer site
Leukemia
Treatment type
Chemotherapy
Drug
Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our results revealed that circPAN3 may be a key mediator for chemo-resistance of AML cells, which may depend on the circPAN3-miR-153-5p/miR-183-5p-XIAP.
Tissue resource
bone marrow specimens from acute myeloid leukemia patients
human acute myeloid leukemia cell lines THP-1
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Fujian Provincial Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.