Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-381
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
MDR1
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-381 could overcome DDP resistance of breast cancer by directly targeting MDR1, providing a novel therapeutic target for breast cancer chemoresistance.
Tissue resource
tumor tissues and matched adjacent normal tissues
human normal breast epithelial cell lines MCF-10A
human breast cancer cell lines MCF-7
human breast cancer cell lines MDA-MB-231
human breast cancer cisplatin-resistant cell lines MCF-7/DDP
human breast cancer cisplatin-resistant cell lines MDA-MB-231/DDP
human embryonic kidney cell lines HEK-293T
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Nanjing Drum Tower Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.