CTRR-ncRNA

ncRNA information

ncRNA name

XLOC_006753

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

PI3K/AKT/mTOR signaling pathway

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil/Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

110

Male patients

81

Female patients

29

Age range and number

64(<=58)+46(>58)

Research information

PMID

30481766

Description

High expression of XLOC_006753 promoted the development of MDR, which was activated by the PI3K/AKT/mTOR pathway in GC cells.

Tissue resource

gastric cancer tumor tissues and corresponding normal tissues

human gastric adenocarcinoma cell lines SGC-7901

human gastric adenocarcinoma 5-FU-resistant cell lines SGC-7901/5-FU

human gastric adenocarcinoma cisplatin-resistant cell lines SGC-7901/DDP

Experiment

qRT-PCR,Western blot

Institute

Sun Yat-Sen University Cancer Center

Guangzhou Medical University

Country

China

Continent

Asia