LINC01118

ncRNA information

ncRNA name

LINC01118

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-134/ABCC1

Cancer information

Cancer name

Ovarian Cancer

Cancer site

Ovary

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

LINC01118 acted as an oncogene and modulated EOC paclitaxel sensitivity by regulating miR-134/ABCC1.

Tissue resource

ovarian cancer tissues

human epithelial ovarian carcinoma cell lines SKOV3-TR30

human epithelial ovarian carcinoma cell lines SKOV3

human epithelial ovarian carcinoma cell lines A2780

human epithelial ovarian carcinoma cell lines COC1

Experiment

RT-PCR,Western blot,Luciferase reporter assay


Institute

the Department of Gynecology of Shengjing Hospital of China Medical University

Women's Hospital, School of Medicine, Zhejiang University

the Tumor Cell Band Research Institute of the Chinese Academy of Medical Science

Country

China

Continent

Asia