Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-506-3p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
YAP1
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Gefitinib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
The downregulation of miR-506-3p contributes to gefi-tinib resistance, and thus, the restoration of miR-506-3p may be a potential therapeutic approach for overcoming NSCLC gefitinib resistance.
Tissue resource
lung adenocarcinoma and adjacent non-cancerous specimens
human embryonic kidney cell lines HEK-293T
human normal epithelial cell lines BEAS-2B
non-small cell lung cancer cell lines PC-9
Experiment
qRT-PCR,Western blot
Institute
Taizhou Central Hospital
the Cell Bank of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.