Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa_circ_0060060
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-144-3p
Cancer name
Anaplastic Thyroid Carcinoma
Cancer site
Thyroid
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
CircEIF6 promoted autophagy by regulating miR-144-3p/TGF-Ī± , enhancing the cisplatin-resistance in PTC and ATC cells. CircEIF6 promoted tumor growth by regulating miR-144-3p/TGF-Ī± and circEIF6 knock-down enhanced cisplatin sensitivity in vivo.
Tissue resource
paired anaplastic thyroid carcinoma tissues and para-carcinoma tissues
normal thyroid cell lines HTori-3
thyroid tumor cell lines TPC1
anaplastic thyroid carcinoma cell lines BHT101
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the First Hospital of Shanxi Medical University
BeNa Culture Collection
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.