OIP5-AS1

ncRNA information

ncRNA name

OIP5-AS1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-340-5p

Cancer information

Cancer name

Osteosarcoma

Cancer site

Bone, Articular Cartilage

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

OIP5-AS1 causes cisplatin resistance in osteosarcoma through inducing the LPAATĪ²/PI3K/AKT/mTOR signaling pathway by sponging the miR-340-5p.

Tissue resource

human osteosarcoma cell line MG63

human osteosarcoma cell line SaOS2

Experiment

qRT-PCR,Western blot


Institute

American Type Culture Collection

Country

USA

Continent

North American