Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-135b
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
MST1-mediated MAPK signaling pathway
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
The results were highly indicative of the crucial role played by MST1 in the development of GC and the sensitivity of GC to CDDP. MiR-135b was found to regulate MST1,which in turn had an impact on the development of GC MKN28 was observed to be most sensitive to CDDP, whereas MKN45 presented with the poorest sensitivity to CDDP.
Tissue resource
human gastric cancer cell lines MKN28
human gastric cancer cell lines NCI-N87
human gastric cancer cell lines SGC7901
human gastric cancer cell lines BGC823
human gastric cancer cell lines MKN45
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay,Microarray analysis
Institute
the Shanghai Institute of Cell Biology, Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.