Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
NEAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-101-3p/FN1/PI3K-AKT signaling pathway
Cancer name
Papillary Thyroid Carcinoma
Cancer site
Thyroid
Treatment type
Radiotherapy
Impact of wild-type ncRNA on radiotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Both in vitro and in vivo, NEAT1 suppression could inhibit 131I resistance of PTC by upregulating miR-101-3p/FN1 expression and inactivated PI3K/AKT signaling pathway both in vitro and in vivo.
Tissue resource
normal papillary thyroid carcinoma tissues and RAI-resistant papillary thyroid carcinoma samples
thyroid papillary cell lines TPC-1
thyroid papillary cell lines B-CPAP
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
the Yunnan Cancer Hospital/the Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Center
BeNa Culture Collection
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.