Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
UCA1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
PI3K/Akt signaling pathway
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Tamoxifen
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
UCA1 regulates the EZH2/p21 and the PI3K/AKT signaling pathway in breast cancer, and may be a potential therapeutic target for solving tamoxifen resistance.
Tissue resource
hormone receptor-positive breast cancer specimens and non-tumor specimens
human breast cancer tamoxifen-sensitive cell lines MCF-7
human breast cancer tamoxifen-sensitive cell lines T47D
human breast cancer tamoxifen-resistant cell lines LCC2
human breast cancer tamoxifen-resistant cell lines LCC9
Experiment
qRT-PCR,Western blot
Institute
the First Hospital of Jilin University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.