CACS15

ncRNA information

ncRNA name

CACS15

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-145/ABCC1

Cancer information

Cancer name

Colorectal Cancer

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

Oxaliplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

CASC15 silencing overcame OXA resistance of CRC by regulating miR-145/ABCC1 , providing a potential therapeutic target for CRC chemoresistance.

Tissue resource

paired tumor tissues and adjacent normal tissues were collected from colorectal cancer patients

human normal colonic epithelial cell lines NCM460

human colorectal cancer cell lines HT29

human colorectal cancer cell lines HCT116

human colorectal cancer cell lines oxaliplatin-resistant cell lines HT29/OXA

human colorectal cancer cell lines oxaliplatin-resistant cell lines HCT116/OXA

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Shanghai Tongji Hospital of Tongji University School of Medicine

the Chinese Academy of Sciences

Country

China

Continent

Asia