Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CACS15
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-145/ABCC1
Cancer name
Colorectal Cancer
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
Oxaliplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
CASC15 silencing overcame OXA resistance of CRC by regulating miR-145/ABCC1 , providing a potential therapeutic target for CRC chemoresistance.
Tissue resource
paired tumor tissues and adjacent normal tissues were collected from colorectal cancer patients
human normal colonic epithelial cell lines NCM460
human colorectal cancer cell lines HT29
human colorectal cancer cell lines HCT116
human colorectal cancer cell lines oxaliplatin-resistant cell lines HT29/OXA
human colorectal cancer cell lines oxaliplatin-resistant cell lines HCT116/OXA
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Shanghai Tongji Hospital of Tongji University School of Medicine
the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.